How to Make DMT: 3 Separate Methods (DMT Extraction & Synthesis) | Buy DMT Online

How to Make DMT: 3 Separate Methods (N, N, DMT & 5-MeO-DMT)

One of the planet’s most profound and well-known psychedelics is DMT (dimethyltryptamine). The preparation of this potent psychedelic is surprisingly simple. The easiest way to make it is to extract it from DMT-containing plants. Still, a basic understanding of chemistry and access to some modest lab equipment may also make it synthetically from materials that are readily available in stores. We’ll go over three different ways to make two types of “DMT” in this article. We’ll go over the natural extraction technique (beginning level), the Hamilton Morris style 5 MeO DMT synthesis (intermediate level), and a technique for creating N, N, DMT (advanced level).

What is DMT?

Dimethyltryptamine, or DMT, is one of the most basic psychedelics in terms of its molecular structure, yet among the most profound in terms of the experience it offers. Although there are several different varieties of DMT, N, N, DMT, and 5-MeO-DMT are the most widely used. Other types of DMT exist as well, although they have quite different effects. Examples include 4-AcO-DMT, which has effects more akin to psilocybin than DMT, and 5-Bromo-DMT, which has highly moderate psychedelic effects. And 4-OH-DMT (the chemical name for psilocin). Although theoretically a kind of DMT, these substances are not to be confused with N, N, DMT, or 5-MeO-DMT.

The Bufo alvarius toad or ayahuasca (N, N, DMT) are the two most popular ways to consume DMT (5-MeO- Dimethyltryptamine). Shamans utilize traditional DMT sources to evoke mystical encounters for healing and self-discovery. Additionally, DMT can be smoked or vaped, which results in a rich but fleeting psychedelic experience. According to studies, DMT can consistently provide mystical experiences helpful in treating mental disease, releasing deep psychological scars, and facing one’s realities. There are many conditions for which DMT may be used as a therapeutic, including existential anxiety, depression, addiction, anxiety, and migraines.

How to Extract DMT From Plants

DMT can be produced most easily by extracting it from plants. Mimosa hostilis root bark, which is easily obtainable online, is the most popular plant. N, N, DMT rather than 5-MeO-DMT or other hallucinogenic tryptamines are found in most plant sources. Additional resources, such as Acacia confusa, Psychotria Viridis, and many more, can also be utilized.

The extraction can be done using short supplies purchased from big-box retailers or online.

Ingredients:

• Plant materials containing DMT can be used, such as Psychotria Viridis, Mimosa hostilis, and Mimosa pudica.
• An example of a nonpolar solvent is naphtha.
• Purified water
• The hydroxide of sodium (lye)
• 5% distilled white vinegar; muriatic acid may also be used

Equipment:

• Nitrile gloves
• security glasses
• A pipette or separating funnel—to separate the DMT-containing nonpolar layer (separation funnels work great too)
• espresso filters
• Several glass beakers or jars; never do these extractions in plastic or metal containers.
• freezer and refrigerator
• a blender or coffee grinder

The Method: Simplicated

• Combine plant matter, vinegar, and water.
• To raise the pH, add sodium hydroxide.
• To separate the DMT part, add naphtha.
• Refrigerate the mixture to separate the DMT.
• Separate the freebase Dimethyltryptamine Powder and dry it.

Process for Extraction of DMT from Plants in Steps

The basic procedure for separating DMT from plant sources is straightforward and can be completed without requiring a lab license by employing chemicals that are easily accessible. You can choose chemicals from a wide range of alternatives, and more sophisticated purification techniques, such as short-path vacuum distillation, can increase process efficiency but are optional.

The simplest way to extracting dmt at home is described in the following process. The most crucial thing to remember is that, despite being widely accessible, the chemicals employed in this process can be extremely harmful if mishandled. Wear gloves and goggles when handling lye since it is caustic and can cause severe chemical burns to the skin and eyes.

Ensure the space is well-ventilated and away from sparks or open flames because naphtha and other solvents are very explosive. To avoid extracting the incorrect plant species, always ensure the raw plant material is obtained from a reliable source. Here is how to extract DMT from plants using the straightforward method, step-by-step:

Step 1: Gently Heat the Plant Material in Water & Vinegar

Start using a coffee grinder or blender to create a fine powder from your dried plant material. Then, gradually include 5% distilled white vinegar into the ground herb (ratio 0.4 mL per gram of dried herb). Muriatic acid is another option that you have for this stage. At a ratio of 3.6 mL water to 1 gram of dried root powder, add distilled water that is nearly boiling (90ºC). Stirring constantly, gradually warm the fluid for about three hours. Use a double boiler, hot plate, or slow cooker. It shouldn’t be boiling, so keep the heat low.

Step 2: Strain to Remove the Plant Material

You can use cheesecloth or a fine strainer to remove the plant matter from the mixture after about a half-hour. What’s left over is a tincture made from the original herb ingredient. It will smell strong and be very black.

Step 3: Basify The Solution

Mix around 5 g of lye (sodium hydroxide) with 100 mL of distilled water to basify the solution. Make sure the pH is between 12 and 13. When the hue changes from a rich purple to a dark black, the pH is over 12. It will darken and heat up as you gently add the solution to the extractor. Before moving on to the next stage, give the combination around 48 hours to sit.

Step 4: Filter & Defat The Solution

The solution is “washed” with a nonpolar solvent, such as naphtha, as part of the defatting process (found at camping stores in the form of fuel for Zippo fluid). A nonpolar phase will gradually begin to float to the top of the liquid after you add the solvent and stir the combination. Allow the mixture to stand for 24 hours to separate completely. Every few hours, lightly shake the jar to combine the solution. Avoid shaking the solution too forcefully, since this can cause it to emulsify and become much more difficult to separate. The DMT will diffuse from the bottom water layer to the top naphtha layer over a few hours.

Step 5: Separate the Top DMT-Containing Layer & Recrystallize

The black bottom layer should be separated from the clear top layer using a separating funnel, turkey baster, or pipette. The DMT is located in the transparent upper layer. Put the remedy in the refrigerator to cool. At the bottom of the solution, which contains almost all freebase DMT, crystals will form. Once the DMT crystals have been separated from the naphtha, you can pass this mixture through a coffee filter. To get rid of the naphtha, let the coffee filters thoroughly dry in a well-ventilated place.

Step 6: Recrystallization & Further Purification

You can smoke the substance you know there. However, recrystallizing it separately to purify the extract better would be an excellent idea. To accomplish this, add a small amount of naphtha to the powder and stir gently until all the ingredients are dissolved. You should gently heat the solution in a double boiler if it doesn’t dissolve. The captcha will begin evaporating at about 40°C, so take caution here. Never heat the solution with an open flame.

Then, put the solution in the freezer for a further few hours after a few hours in the fridge. Instead of merely putting the solution in the freezer, it’s vital to enable it to chill gradually by bringing it to room temperature, fridge temperature, and finally, freezer temperature. To receive a good yield, you need to cool the jar in the freezer before refrigerating it.

The DMT will eventually create fresh crystals in the jar’s bottom, which will be purer than the initial collection of crystals you created in step 4. Use a coffee filter to separate the crystals from the naphtha. Should spread the powder out on a dish and completely dry. As the naphtha evaporates from the powder, ensure adequate ventilation so you may adequately remove it.

How Pure is the Final Extract?

Freebase N, N, DMT, and several other unidentified chemicals taken from the plant are all left. Although this approach is dependable for manufacturing DMT (dimethyltryptamine) in high concentrations, it can only be partially pure with additional lab purification procedures. The same procedure will be used to extract additional plant-based chemicals. It may isolate certain chemicals depending on the source of the plant’s raw material, the solvents employed, and other elements.

How to Synthesize 5-MeO-DMT

It is more challenging to synthesize 5-MeO-DMT than to extract it from plants, and it also calls for a much more sophisticated lab apparatus. Despite this, it’s still a relatively straightforward procedure that can be carried out correctly and safely by anyone with a fundamental knowledge of chemistry and lab procedures. Hamilton Morris’s video effectively demonstrated a modified Eschweiler–Clarke reaction employing 5-methoxy-tryptamine as the initiating compound (already legal and commercially available).

The reaction requires one reaction to achieve the entire transformation. After being produced, 5-MeO-DMT is purified, purified again, and tested.

Ingredients:

• 5-Methoxy-Tryptamine
• Methanol
• Potassium Oxygen
• Formaldehyde
• Cyanoborohydride of sodium

Equipment:

• Flushing condenser
• Response chamber
• Spindle Evaporator
• Thermometer
• two extra-large funnels

The Method: Simplicated

• Slowly combine formaldehyde, sodium cyanoborohydride, and 5-methoxy-tryptamine.
• Remove the 5-MeO-DMT that rises to the surface.
• Cleanse by distilling and recrystallizing
• Test the finished product.

Step-By-Step Process:

Finding a source of raw 5-MeO-tryptamine freebase, which is completely legal and available from chemical merchants or wholesalers, is the most straightforward approach to creating 5-MeO- Dimethyltryptamine. Depending on where you reside, this product has a wide range in price.

Step 1: Dissolve the 5-methoxy-tryptamine-free base in methanol

To speed up the reaction, the powdered 5-MeO-tryptamine must first be dissolved in methanol or a similar solvent. This substance is easily accessible (legally), and melatonin is typically made from it. Just one reduction process is needed for this molecule to transform into 5-MeO-DMT.

Step 2: Cool the Mixture to 0ºC

The reaction vessel and the 5-MeO-tryptamine are chilled to 0oC using an ice bath or chiller.

Step 3: Slowly Combine Formaldehyde and Sodium cyanoborohydride

Add the reducing chemicals gradually into the reaction vessel using the two extra funnels. It is best to add these ingredients while swirling continually slowly.

Step 4: Evaporate the Methanol

Overnight, gently boil the mixture to cause the methanol to evaporate. On the liquid’s surface, 5-MeO-DMT “oil slicks” develop as the methanol evaporates.

Step 5: Purify the 5-MeO-DMT

It is now necessary to separate the 5-MeO-DMT from the other components of the mixture. Short-path vacuum distillation concentrates the crude DMT freebase, while distillation eliminates the water. The last step is to recrystallize the 5-MeO-DMT, which is done by re-dissolving the natural extract in warm methanol and putting the mixture in the refrigerator to set crystals for a few hours.

How to Synthesize N, N, DMT

The most challenging of the three procedures, synthesizing N, N, and DMT, takes a much greater level of ability and experience to complete safely and effectively. The chemicals required to run the extraction are also more challenging to find and highly poisonous, corrosive, and explosive.

Ingredients:

• Oxalates of Chloride
• Diacetyl ether
• Aluminum lithium hydride
• Ether
• Purified water
• Tetrahydrofuran
• Dioxane
• Magnesium sulfate in anhydrous form
• gasoline petroleum
• Chlorine in hydrogen

Equipment:

• Flushing condenser
• reaction container
• Discrimination filter

The Method: Simplicated

• Diethyl ether is used to dissolve tryptamine.
• To create N, N, and DMT, react with the reagents.
• Create the DMT Salt
• Recrystallize and eliminate all solvents.
• Test the finished item.

Step-by-Step Guide to Synthesis of N, N, DMT

Alexander Shulgin described the following approach in his book PIHKAL. To carry out this operation properly, you’ll need prior lab knowledge and access to various lab tools.

Step 1: Dissolve Tryptamine With Diethyl Ether

Tryptamine, the precursor for N, N, and DMT, must first be dissolved using diethyl ether. In order to make sure that all of the tryptamine is dissolved, stir it around for a while.

Step 2: Combine Tryptamine Solution With Oxalyl Chloride

Add the oxalyl chloride next because it serves as a reagent to create indole oxalyl chloride, which bridges the beginning material (tryptamine) and the finished product (N, N, DMT). A yellow crystalline substance that forms during this reaction settles out of the solution on the bottom of the container.

Step 3: Add Dimethylamine

The indole oxalyl chloride is subsequently reacted with a substance called dimethylamine. The subsequent chemical intermediate, indol-3-yl-N, N-dimethyl oxamide, is created as a result. A white precipitate should start to form at the bottom of the container after several minutes of solution stirring.

Step 4: Remove the White Substance From the Liquid

To get the white component out of the container, filter the mixture. You should thoroughly clean it with ether and water to remove the diethyl ether before letting it dry in a well-ventilated place.

Step 5: Add Lithium Aluminum Hydride

Add the white powder from step 4 to a tetrahydrofuran solution of lithium aluminum hydride. After several hours of refluxing, let the entire solution settle to room temperature. You’ll need to add some dioxane to eliminate any extra hydroxide that remains after the reaction. When combined, white sediment containing Dimethyltryptamine and other impurities that need to be destroyed should form at the bottom of the reaction jar.

Step 6: Filter, Wash, & Dry

Remove the white DMT-containing powder by filtering the mixture. Repeatedly rinse it with tetrahydrofuran, then use anhydrous magnesium sulfate to dry the powder.

Step 7: Recrystallize The Impure Powder

The powder you have now has a significant amount of DMT, but it isn’t pure. Before it can use safely, you must clean it. Put the powder in a solvent, like petroleum ether, and slowly heat the mixture to dissolve it entirely. To enable the formation of DMT crystals, allow the solution to cool to room temperature. To get the DMT to dissolve, you should put the solution in the refrigerator.

The powder should be filtered and air-dried in a well-ventilated area. At this stage, you still don’t have pure DMT.

Step 8: Create DMT Salt

Combine the powder with hydrogen chloride and anhydrous diethyl ether (anhydrous). The result of this reaction is the hydrochloride of N, N, DMT. It is a DMT salt that will be stable over the long term. After filtering, let the powder dry.

Step 9: Recrystallize Once More

While slowly heating, add the powder to methanol or benzene. Remove from fire once all the powder has dissolved, then let it cool. The container will gradually crystallize DMT hydrochloride, which can then be filtered and dried by air one last time. The result is N, N, dimethyltryptamine hydrochloride, which is almost entirely pure.

Critical: Lab Safety

Although it isn’t particularly difficult to make must use DMT, hazardous and highly combustible materials in its preparation. It’s crucial that anyone making dmt substance is aware of the risks and how to reduce their likelihood of experiencing them.

Mistakes can (and do) lead to explosions, fires, and potentially fatal exposure to dangerous substances, even in a fully-equipped laboratory. When performing work in a lab, keep the following things in mind:

1. Constantly put on gloves and safety glasses

Many of the compounds used in the extraction or synthesis of DMT are either poisonous, flammable, or caustic (create chemical burns), which are all excellent justifications for wearing protective clothing to prevent harm.

You may think these precautions are unnecessary because you’ve “never had an incident before,” but this is an error in logic that you don’t want to discover the hard way. Even if things have gone off without a hitch in the past, it doesn’t necessarily follow that they will only work in the present. These substances can permanently harm the body if they get up in the eyes, skin, or lungs.

2. Check That You Have Enough Ventilation

Naphtha is one of many highly flammable solvents. These substances are heated throughout some phases, which causes them to evaporate into the atmosphere. If there isn’t enough airflow to remove these substances as they disappear, they could become hazardous if inhaled or come into contact with a spark or flame and ignite a fire. It is advisable to carry out these activities in an area of the workshop with HVAC systems installed, or at the very least, leave the garage door ajar and turn on a fan to circulate air from within the garage outside.

3. Recognize the chemicals you’re utilizing.

Some ingredients in the recipe above are also present in over-the-counter cleaners like Draino. These cleaning solutions aren’t pure, though. The other additions might be harmful or produce unidentified hazardous consequences. Use lab-grade chemicals wherever possible, and be sure you know the steps you’re doing before starting.

4. Never use an open flame to heat your solvents.

A fire may start if some of the solvents that evaporate into the air come in contact with an open flame or spark (including static electricity) like point number two. Make sure there are no open flames present before you start. Don’t smoke, don’t use your vaporizer, and do nothing else.

5. Before using your finished product, test it.

Even the world’s top chemists evaluate the finished product to confirm its purity. While DIY extractions carried out in a garage are likely to need more access to a mass spectrometry device, there are other, less sophisticated ways to verify the end products are what they claim to be.

To test a finished product sample, get some harm-reduction reagent kits. This won’t demonstrate the purity of the finished product, but it will guarantee that you didn’t utterly miss the mark and produce something entirely different.

DMT’s Chemical Composition

DMT is categorized as an indole alkaloid, the same categorization as many hallucinogenic substances such as psilocybin and LSD (lysergic acid diethylamide) (magic mushrooms). Serotonin, melatonin, and the amino acid tryptamine have this basic structure.

There are more than 4000 indole alkaloids, many of which have pharmacological effects on people. All indole alkaloids share the same basic structure: a 6-sided benzene ring joined to a 5-sided pyrrole ring. One of the simplest psychedelics known is the DMT molecule. Its molecular weight is hardly more than that of glucose. It can pass the blood-brain barrier much more quickly than other psychedelics due to its tiny size.

The Production of DMT Through Time

Ayahuasca, the earliest method of DMT extraction, is found in the Amazon. A succession of harmala alkaloids from the ayahuasca vine and water extracts of DMT from local plant species make up the ayahuasca drink (Banisteriopsis caapi).

The Canadian chemist Richard Helmuth Frederick Manske created N, N, DMT for the first time in a lab setting in 1931. Manske didn’t know the chemical he invented had hallucinogenic properties at the time. Later, in 1946, Oswaldo Gonçalves de Lima of Brazil was the first to extract N, N, DMT from Mimosa hostilis bark. Numerous research has been published recently that emphasize novel methods or technologies for producing and extracting synthetic DMT.

Large-Scale Production of Dimethyltryptamine

The techniques above are the simplest to use. However, they may not be the most effective when used comprehensively. Excellently summarized the techniques utilized to manufacture 5-MeO-DMT at scale in a paper released in late 2020. Instead of optimizing for simplicity or cost reduction, these techniques maximize the potency and consistency of output from one batch to the next.

Three procedures for creating 5-MeO-DMT from various starting materials were described in this study:

1. The Eschweiler–Clarke Reaction with Modification

• unidirectional reaction
• simple method
• arduous to scale

This methodology is the one-step procedure described above and used by Hamilton Morris to demonstrate the synthesis of 5-MeO-DMT.

Although it is reasonably simple to use, it depends on having access to 5-MeO-tryptamine, which is currently legal and widely available commercially. The precursor has already undergone most of the difficult work. Thus all that is required to transform the molecule into 5-MeO-DMT is a straightforward reduction reaction.

2. The Speedster–Anthony Synthesis of Tryptamine

• Over 90% conversion effectiveness
• arduous to scale
• needs components that are sensitive to oxygen

The scholarly literature most frequently refers to this technique. It is utilized to produce certain psychedelic tryptamines, such as psilocybin and psilocin. The Fischer indole reaction is gradually replacing this procedure since it can scale it up more quickly.

3. The Fischer Indole Reaction

• the conversion efficiency of 80%
• one-step procedure
• Low temperatures
• takes place in an aqueous solvent
• can be applied to both N, N, DMT, and 5-MeO-DMT

Because it can scale up, it only requires one reaction step, happens in an aqueous solvent, and doesn’t involve high temperatures (which makes it less dangerous). It doesn’t require air-sensitive or pyrophoric reactants and uses straightforward, widely accessible ingredients. This process is the best one for large-scale production.

Utilizing DMT

The above-described methods result in a fine, white-to-brownish powder that is DMT. How to utilize freebase DMT powder is as follows:

1. Vape It

The simplest way to use DMT is to vaporize it. There are two primary methods for doing this: Create a DMT-charged E-Liquid by mixing the powder with a commonly available online E-liquid base, then adding the DMT-charged E-juice to a vape pen. Although you can make the juice as potent as you like, a 1:1 ratio is the most typical. This means that for every 1 mL of e-liquid, you must add roughly 1 gram of DMT powder.

Use a mesh or mod vape pen to inhale raw DMT powder; these devices have a stainless steel mesh to keep the powder above the heating element. The ideal approach for single-hit innovations is this one. The drawback of these gadgets is that they are more expensive and require some adjustment to function effectively.

2. Smoke It

You can use a bong or pipe to smoke DMT. No matter how you smoke it, it won’t be enjoyable. Some people prefer to smoke DMT through crack-style pipes since they can better regulate the temperature than by putting the flame on it directly. You must always weigh DMT powder before use. This thing is quite durable.

3. Eat It

Direct ingestion of DMT powder has no effect. For it to function, you must first combine it with a monoamine oxidase inhibitor. Nobody should do this without sufficient expertise and supervision from knowledgeable users because it is a tricky affair. Herbal MAO inhibitors and pharmaceutical MAO inhibitors are the two types of MAO inhibitors to take into account.

Pharmahuasca is the name of the substance that most people utilize for this. The idea is to mimic ayahuasca using artificial substances. This entails combining DMT with an approved MAO inhibitor, such as isocarboxazid (Marplan). Marplan is a potent medication with an extensive list of potential side effects, making this combination potentially hazardous.

Syrian Rue and Ayahuasca vine are two herbal possibilities. You can use them with DMT to make a potent tea. Using this strategy, the experience will have a wide range of psychoactivity, from hardly psychoactive to highly psychoactive.

Final thoughts: DMT Production

DMT production is simpler than you think. The simplest way to make it is to extract and concentrate it from plants, but it may also be produced synthetically using only a few essential chemical reactions.

Could supply the continent with DMT from a single lab. Currently, methods with above 80% efficiency in producing 5-MeO-DMT and N, N-Dimethyltryptamine are being investigated. Before DMT manufacturing spirals out of control, we must establish the standard early. According to history, various immoral players enter the scene when narcotics become widespread. The integrity these manufacturers maintain over their manufacturing process may be lower than we require. As a result, dangerous, falsified, or subpar Dimethyltryptamine might be released onto the market.