A prodrug of the hallucinogenic component in magic mushrooms is 4-AcO-DMT, sometimes known as synthetic mushrooms (psilocin). Except for a few minor subjective variations, the experience is nearly identical to that of magic mushrooms.
The long-held patents for this substance have long since expired, endangering efforts by businesses like Compass Pathways to control the synthetic psilocybin industry for the foreseeable future.
What is 4-AcO-DMT?
The acronym for 4-AcO-DMT is 4-Acetoxy-DMT. It was created by Albert Hofmann and Franz Troxler, two of the people responsible for creating LSD (lysergic acid diethylamide). It was created in the early 1960s due to the pair’s investigation of the psychoactive compounds in psychedelic mushrooms.
A derivative of the major pharmacological ingredient in magic mushrooms, psilocin, is 4-AcO-DMT. The liver transforms psilocybin and 4-AcO-DMT into psilocin, producing hallucinogenic effects. As a result, 4-AcO-effects DMTs are nearly identical to psilocybin or psilocin.
The Sandoz firm, for which the team was working, filed a patent in January 1963 but never allowed it to be used for financial gain. Simply put, they had no idea what to deal with this or any other psychotropic compound produced by Hofmann (including LSD and psilocybin). This happened soon after the Timothy Leary and Richard Alpert-led Harvard Psilocybin Project. Leary received a lot of LSD from Sandoz so that he could study it and look for potential lucrative uses in the field of psychotherapy.
For many years, 4-AcO-DMT was ignored until the late 1990s, when a man named David E. Nichols started advocating for its use in psychedelic-assisted psychotherapy. He hoped to inspire scientists to investigate this substance further so that it would ultimately enter the medical system. Nichols praised it because of its potency, affordability, and dependability of results. Unfortunately, a clinical investigation has yet to be done to examine the effects of 4-AcO-DMT. The majority of the knowledge that is currently accessible comes from anecdotal stories and studies conducted on animals.
4-AcO-DMT is one of the most widely used synthetic psychedelics, ranking higher than 2C-B, Dipt, and other 2C-X family members but less well studied than LSD and ketamine. In its unprocessed state, 4-AcO-DMT is a yellowish-brown powder often offered in capsule or tablet form.
What Does 4-AcO-DMT Feel Like?
4-AcO-DMT generally reproduces the effects of psilocybin mushrooms. The substance’s active component is the main metabolite of 4-AcO-DMT, psilocin. As a result, psilocin, a naturally occurring hallucinogenic, is a prodrug of 4-AcO-DMT. 4-AcO-DMT and magic mushrooms are practically identical at lesser doses (up to 30 mg). It causes auditory and visual hallucinations, strengthens existential and introspective thought processes, inhibits the default mode network (DMN), and modifies the perception of time and sensory data.
The effects of 4-AcO-DMT start to alter with greater doses (above 30 mg). This dosage is quite potent and more closely resembles DMT. The hallucinations, empathy and introspection intensify, and the pictures become much more fractal and geometric. One of the key causes of why so many people only use this drug once is the existential weight of the material, especially in greater doses. It is not known why high doses of 4-AcO-DMT are considerably more likely to result in frightful or unpleasant trips than high doses of magic mushrooms. We have 11 reports of people using 4-AcO-DMT from our trip surveys. Most users consumed between 20 and 30 mg, reporting effects that were somewhat mellower than magic mushrooms but still extremely similar.
Common 4-AcO-DMT Effects Reported:
- altered temporal perception
- geometric fractal patterns
- The way people perceive music can change, sometimes for the better.
- whole-body floating feeling
How Long Does 4-AcO-DMT Last?
The length of effects is one of the primary distinctions between 4-AcO-DMT and mushrooms. The duration of this drug ranges from two to six hours. Like magic mushrooms, it doesn’t always last for the full eight hours. The effects will start and cease sooner if you take 4-AcO-DMT on an empty stomach or snort the powder instead of taking it as a capsule.
For instance, you should allow up to 45 minutes for 4-AcO-DMT to begin working if you take it as a capsule. Peak experience starts at roughly two hours and gradually fades away over the following two to four hours. If you insufflate (snort) the powder, the effects kick in after approximately 15 minutes, peak after an hour, and then taper off over the next two to three hours.
What’s the Dose of 4-AcO-DMT?
The consistency of its effects is one of 4-AcO-key DMT’s benefits and why proponents like David Nicoles are so enthusiastic about it. Compared to more natural psychedelics, the intensity of effects is much simpler to assess with this pure molecule due to its quick and predictable metabolism. Because the concentration of the active components might differ greatly from sample to sample, plants, and fungi are more difficult to dose.
The typical 4-AcO-DMT dosage varies from 10 to 30 mg. Some people (microdose) take less, while others (full Dose) (heroic Dose). Subjectively, a dose of 20 mg is roughly similar to 3 grams of dried psilocybin mushrooms. When utilizing 4-AcO-DMT for the first time, starting at the low end of the spectrum is best and gradually working your way up. The Dose is slightly influence by the type of 4-AcO-DMT use. For instance, you would require roughly 1.24 mg of powder if you were using 4-AcO-DMT fumarate salt. You need 1.15 mg of powder if you’re using the salt form of 4-AcO-DMT. Furthermore, inhaling the active components rather than taking them orally results in a dose of around 20% lower.
To get you started, here are some general dosing instructions:
- 1-2 mg is a microdose.
- the 5 mg threshold dose
- Small Dose 10–20 mg
- Typical Dose 20–30 mg
- Herculean Dose 40+ mg
How Do Other Psychedelics Compare to 4-AcO-DMT?
Although it also has similarities to other indole alkaloids like LSD, N, N, DMT, and 5-MeO-DMT, 4-AcO-DMT is most comparable to psilocybin and psilocin. Its homologs include 4-AcO-MET, 4-AcO-DET, 4-AcO-MiPT, and 4-AcO-DiPT, all psychotropic research compounds.
4-AcO-DMT vs. Psilocybin
4-AcO-DMT is also known as synthetic mushrooms. This is so because 4-AcO-DMT is processe within the body in the exact same manner as magic mushroom active components. The psychedelic effect is brought on by the brain’s 5-HT2A receptors when it is transforme into psilocin.
An analogue of psilocybin (4-PO-DMT) and psilocin is 4-AcO-DMT (4-HO-DMT). Most people won’t be able to discern the difference between the 4-AcO-DMT experience and that of magic mushrooms or even synthetic psilocybin because these substances have more similarities than differences. However, there are a few minute variations between these compounds.
4-AcO-DMT, for instance, is mellower than magic mushrooms when consumed in smaller quantities. It’s more composed, reflective, and acute. Magic mushrooms frequently result in fuzzy sensations. Making decisions can be challenging, and vision may need to be clearer. When utilizing 4-AcO-DMT, this isn’t as obvious. The onset times are another point of distinction. If you inhale it or take it on an empty stomach, 4-AcO-DMT takes effect rather quickly. The effects of magic mushrooms can take an hour or longer to begin, whereas 4-AcO-DMT often begins to work within 30 to 45 minutes.
The frequent side effect of taking magic mushrooms, nausea, is considerably less likely to occur while using 4-AcO-DMT. The most plausible explanation is that 4-AcO-DMT doesn’t include chitin or fibers that might irritate the gut lining and are present in magic mushrooms. 4-AcO-DMT begins to set itself apart from magic mushrooms at greater doses. The effects resemble DMT more when taken in large dosages (above 40 mg). Even more so than high doses of magic mushrooms, it causes strong fractal and geometric hallucinations and profound existential “realisations.”
4-AcO-DMT vs. 5-MeO-DMT
The hallucinogenic compound released by the Bufo alvarius toad, 5-MeO-DMT, is structurally extremely similar to 4-AcO-DMT. Although the effects are the same (both substances stimulate the 5-HT2A receptors), the intensity of the sensation is very different. Synthetic mushrooms produce similar psychedelic effects as magic mushrooms, LSD, 2-CB, and LSA. It can alter our perception of time and space, affect how we interpret sensory data, and expose the mind to more entropy. The mystical experience and existential realizations accompanying these encounters are believe to be influence by higher entropy.
In contrast, 5-MeO-DMT is on a different level. It is almost impossible to put into words how profound and unique this experience is. Users frequently have completely out-of-body experiences during which they are cut off from reality and the world they know. The duration is the other key distinction. While 4-AcO-DMT often lasts up to 6 hours, 5-MeO-DMT only lasts 15 to 30 minutes.
4-AcO-DMT vs. LSD
While the effects of 4-AcO-DMT and LSD or its substitutes are similar, they each have distinctive features. While 4-AcO-DMT has more of a bodily high and is thought to be “more grounde,” LSD (Lysergic Acid Diethylamide) tends to be more visual and clear-head. The same receptors are the target of both substances, albeit at differing ratios of binding strength. The 5HT2A receptors, which are responsible for most of the psychedelic effects, are the primary target.
Online stores frequently sell 4-AcO-DMT with a substance called 1P-LSD (especially in Canada, where both compounds are legal). Similar to how 4-AcO-DMT is the prodrug for psilocybin, 1P-LSD is the precursor of LSD. The LSD derivatives PRO-LAD, AL-LAD, LSZ, ETH-LAD, and ALD-52 also compare favorably.
How safe is 4-AcO-DMT?
An impressive safety profile exists for 4-AcO-DMT. The past ten years have seen a lot of interest in it. However, there have never been any significant safety issues with its use. Even at high doses, psilocybin, psilocin, LSD, DMT, and LSA have relatively few adverse effects on the body compared to most indole alkaloids. These chemicals have all undergone thorough testing to determine their safety characteristics. There has never been a mortality associated with the use of 4-AcO-DMT alone. Other medicines have been link to a few fatalities. There is some chance of psychological harm from using this substance, as with any psychedelic substance. 4-AcO-DMT usage could probably exacerbate or precipitate psychotic breakdowns.
Ontological shock can result from full psychedelic experiences if the person isn’t prepare or didn’t have the tools to handle them well. Long-term psychological suffering, such as post-traumatic stress disorder (PTSD), depression, and anxiety, may result from this. Since taking too much of this medication is simple, dosage and adulteration with potentially hazardous substances like fentanyl, PCP, or NBOMe are the main safety concerns. It’s considerably simpler to contaminate dangerous substances since it’s a chemical powder. Never assume your 4-ACO-DMT is pure without first testing it.
Always use a drug testing kit to check your drugs. For this, I like to use the kits from Elevation Chemicals. Reagent test kits are a crucial component of responsible substance usage, especially when handling powders or liquids. You should always test anything that isn’t a raw plant or fungus to be sure the material you’re taking is what you think it is.
Please be aware that reagent testing cannot determine the purity of a sample; it can only reveal the sorts of compounds that are present. This is a step in harm reduction and does not vouch for the sample’s absolute safety. Only a small amount of your drug is needed for testing, and the reagents are quite affordable. For each test, a drop and a sample the size of a sand grain are all required. Testing is rapid, affordable, and effective at ensuring consumer safety.
How to test 4-AcO-DMT:
Four tests with the Ehrlich, Marquis, Mecke, and Mandelin reagents would be conducted in an ideal scenario. Each examines a distinct chemical. The Ehrlich reagent, used to find indole alkaloids, would be the most crucial test if you were on a tight budget. If it doesn’t pass this test, meaning it doesn’t become purple, then the chemical you have is not 4-AcO-DMT, and you should stay away from it at all times.
Place a small sample on a white ceramic or plastic surface to conduct the test. The sample should be around the size of a salt grain. Then, observe how long it takes for the sample to change color after being exposed to one drop of the test reagent. Before noting the hue, wait three minutes to let the reaction finish. If you use the four test reagents mentioned above and your sample is 4-AcO-DMT, you can anticipate the following:
- Ehrlich — Used to identify indole alkaloids is Ehrlich. It ought to turn purple after two minutes.
- Marquis — A tool for amphetamine detection. It shouldn’t alter in hue.
- Mecke — A device for locating opioids. The presence of opiates is indicated by light green or blue color. It may change to a dark green hue.
- Mandelin — Used to distinguish between various alkaloids. Should either stay yellow or turn dark green (not red, black, or orange)
Side Effects of 4-AcO-DMT:
4-AcO in concentration has a high potency. In contrast to mushrooms, which require many grams to provide the appropriate Dose, powder is just only a few milligrams to deliver a significant dose. The effects will remain the same if you eat a few mg of magic mushrooms too much. Even a few extra mg of 4-AcO-DMT can significantly alter the experience. Instead of being peaceful and uplifting, lower doses of 4-AcO-DMT are more likely to produce a more difficult trip. That is so, 4-AcO-DMT rarely causes physical negative effects. Here are some of the 4-AcO-DMT adverse effects that participants in our trip surveys for the drug experienced, along with their personal experiences.
The following are possible negative effects of 4-AcO-DMT:
- sickness and vomiting
- heart flutters
- The face and chest are flushed.
Is 4-AcO-DMT Legal?
Most places in the world fall into a legal grey area regarding 4-AcO-DMT. Regulators mostly ignored it, and neither the United States nor Canada’s lists of restricted chemicals nor the UN Convention on Psychotropic Substances specifically includes it by name. Technically acceptable in Canada, this substance is freely accessible from online sources.
Things are a little bit different in the United States. Despite not being identified, 4-AcO-DMT is a prohibited analog of psilocin. Although it is doubtful that will arrest anyone for possessing 4-AcO-DMT, it is theoretically a Schedule I narcotic under the Federal Analogue Act. Thus, it is feasible that under the Misuse of Drugs Act of 1971, 4-AcO-DMT is classified as a Class A substance in the UK. 4-AcO-DMT is a Schedule 9 substance in Australia, implying that we can only sell it with a buyer’s permission. Australia doesn’t appear to be issuing permits for 4-AcO-DMT, and we have yet to uncover any instances of it being legally sourced there.
How 4-AcO-DMT Works
4-AcO binds the 5-HT2A serotonin receptors, just like most indole psychedelic alkaloids. The brain’s Default Mode Network (DMN) is assumed to be suppressed by these receptors to function. This network is in charge of regulating the flow of information among various brain areas. It functions as a reducing valve, restricting the information that enters the brain and inhibiting some brain functions. This system aims to increase productivity and shield us from feeling overburdened at unimportant events.
This reduction valve is left wide open when the DMN is inhibited through psychedelics like 4-AcO-DMT. As a result, the brain can respond to introspective thoughts and sensory awareness at a far higher degree. This condition improves our capacity for original thought and creativity, modifies how we experience time and sensory data, and awakens memories and emotions that the brain would normally suppress. As a result, we experience visual and auditory hallucinations, a profound state of introspection, ego death, dissolution, and a powerful sense of connection to the outside world.
The majority of indole and phenethylamine psychedelics produce this feeling. All of these substances have various affinities for other serotonin receptors, as well as NMDA receptors, GABA, and many other receptors, but they all work by targeting the same receptors to produce their effects. This is why, even though they all essentially perform the same thing, psychedelic effects are so different.
Frequently Asked Questions About 4-AcO-DMT
Despite being used since the 1960s, there are still many things concerning 4-AcO-DMT that still need to be discovered. This substance’s potential use in psychotherapy or for the treatment of ailments like cluster headaches or anxiety has not yet been the subject of any high-quality clinical research. Both of these applications for psilocybin have already shown great promise. Nevertheless, the following are some of the most typical inquiries we receive from users of 4-AcO-DMT about its use:
What shade of 4-AcO-DMT should it have?
There are two basic types of 4-AcO-DMT, and each has a distinct color. The powder form of 4-AcO-DMT hydrochloride is yellowish brown. There are times when the powder is incredibly fine, like flour, and others when crystals may form. The salt form of 4-AcO-DMT fumarate is also pale brown, albeit it is typically a little darker. Color by itself is not a good indicator of purity. For this, a reagent test kit will be require. You should be extremely cautious and examine the item before using it if you find granules that are dark brown, black, or pure white.
Is 4-AcO-DMT Produced at Home?
Technically, you can synthesize 4-AcO-DMT using some standard lab reagents and equipment. However, it is strongly advised that you leave this to the experts. Although making 4-AcO-DMT and related chemicals isn’t very difficult, many possible reaction errors could result in potentially dangerous byproducts. On top of that, it’s generally prohibite in most nations. Having said that, if you’re interested in learning how to make 4-AcO-DMT, some information is accessible.
From Where Can I Purchase 4-AcO-DMT?
You’re out of luck if you live in the United States. Since this substance is prohibite in the US, no trustworthy sources sell it. Although purchasing it from street sellers is unlawful, it is highly likely that the goods will be contaminate or adulterate. We advise against ordering illegal drugs, including 4-AcO-DMT. You can really get this substance lawfully if you reside in Canada from businesses like ChemLogix. Four normal dosages only cost about $25, making it incredibly cost-effective (25 mg each).
The Prospects for 4-ACO-DMT
Even though 4-AcO-DMT has been around for a while, it was completely unknown until around ten years ago. Since then, demand for this drug has increased, and it is currently one of the most widely available synthetic psychedelics on the market.
Over the ensuing years, we anticipate that interest in 4-AcO-DMT will increase further. Several businesses are currently producing their synthetic form of psilocin or psilocybin, although most seek to patent the finished item. By doing this, they will be able to raise the price of the good and create a monopoly over its management. The patent protection period for 4-AcO-DMT has already expired and is currently in the public domain. This indicates that the drug will always be affordable, even when more businesses enter the market and psychedelics become legal.
In addition to having additional advantages in dosage uniformity, this psychedelic is easy to prepare and provides all the same advantages and experiences as magic mushrooms. Although repeated doses of magic mushrooms, depending on the specific mushroom used, could produce a wide variety of intensities, 20 mg of 4-AcO-DMT will always produce effects of the same intensity. Due to its far more predictable effects, 4-AcO-DMT is a superior choice for psychedelic-assisted psychotherapy.